Projects of 2019
Despite a strong genetic contribution to obesity and diabetes, genome wide association studies have identified variants that can only explain less than 10% of the observed heritability. This discrepancy... read more
keywords: Phenotypic variation, epigenetic inheritance, epigenetic modifiers, mouse phenotyping, complex diseases, epigenomics
Supervisor: Raffaele Teperino, PhD
Group: Environmental Epigenetics Group
Institute: Institute of Experimental Genetics
Most of the reactions that modify chromatin require metabolites as cofactors, suggesting an intimate link between epigenetic regulation and the metabolic state of a cell. We will make use of the nematode C. eleganss... read more
Keywords: nuclear organization, chromatin, metabolism, C. elegans, epigenetics, microscopy
Supervisor: Dr. Daphne S. Cabianca
Group: Environmental and Nuclear Organization
Institute: Institute of Functional Epigenetics
From epidemiological studies and experimental data, we know that chronic diseases accelerate the ageing process, suggesting that ageing and chronic diseases share common mechanisms. In human and mouse models... read more
Keywords: ageing, liver, non-alcoholic liver disease, single cell genomics, computational analysis, integration single cell data
Supervisor: Dr. Celia P. Martinez-Jimenez
Group: Molecular ageing
Institute: Helmholtz Pioneer Campus
This project will address a central question in epigenetics: what are the mechanisms via which the cellular environment controls genome function and the transcriptome? Read more
Keywords: chromatin, modification, epitranscriptomics, cancer, Crispr/Cas9
Supervisor: Prof. Dr. Robert Schneider
Group: Chromatin Dynamics and Epigenetics
Institute: Institute of Functional Epigenetics
All biological processes are implemented by individual cells, of which the human body contains an unimaginable number (approximately 10^13). Surprisingly, it is completely unclear how it is guaranteed... read more
Keywords: CRISPR, Neural Stem Cell, Epigenomic editing, dCas9, Transcriptional engineering, gRNA libraries
Supervisor: Dr. Stefan H. Stricker
Group: Epigenetic Engineering
Institute: Institute of Stem Cell Research
Vertebrate eggs have the remarkable ability to induce nuclear reprogramming of somatic cells to enable the production of any other cell type of an organism upon nuclear transfer. During this process, the memory of cells, which is established by epigenetic mechanisms can be fully erased... read more
Keywords: Nuclear Reprogramming, Epigenetic Memory, Totipotency, Cell fate stability
Supervisor: Dr. Eva Hörmanseder
Group: Maintaining and Reprogramming Cell Fates
Institute: Institute of Epigenetics and Stem Cells
Chromatin modifications, such as DNA and histone methylation, depend on metabolic intermediates as cofactors used by the chromatin modifying enzymes. Plants undergo extensive metabolic changes between day and night, but the resulting implications for chromatin... read more
Keywords: Epigenetic regulation, one-carbon metabolism, chromatin, plant, circadian clock, climate change
Supervisor: Dr. Martin Groth
Group: Epigenetics and acclimation
Institute: Institute of Biochemical Plant Pathology
Transcription and replication are the two major DNA metabolic processes in cells. Both machineries involve large protein complexes progressing along the DNA at high speed and for long distances. Importantly, a large body of evidence suggests that... read more
Keywords: Transcription, Replication, Epigenetic Instability, Episomal System, ChIP, DNA-FISH
Supervisor: Dr. Stephan Hamperl
Group: Chromosome dynamics and genome stability
Institute: Instittute of Epigenetics and Stem Cells
To achieve accurate packaging of DNA into chromatin, cells need to precisely control the concentration of histone proteins, the building blocks of nucleosomes. Typically, histone production is tightly linked to DNA replication... read more
Keywords: histone homeostasis, mouse embryo, transcription, smFISH, qPCR, cell size
Supervisor: Dr. Kurt Schmoller
Group: Cell and Organelle Size Control
Institute: Institute of Functional Epigenetics