Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt

Crosstalk between cellular metabolism and modifications on chromatin

I am a BSc in Biological Sciences and a MSc in Functional and Molecular Biology. During my Bachelor’s and my Master’s, I worked in the laboratory of Nutrition and Cancer (Prof. Dr. Gomes-Marcondes, UNICAMP, Brazil), studying the influence of a maternal fish-oil-rich diet on the cancer-cachectic offspring. The interface between environmental stimuli and gene expression intrigues me, therefore epigenetics has always been my biggest interest. Thus, for my PhD, I joined the group “Chromatin Dynamics and Epigenetics” of Dr. Robert Schneider, in the Institute of Functional Epigenetics (Helmholtz Munich). My PhD project is focused on how the links between metabolic enzymes and chromatin modifiers regulate histone and DNA modifications. Even though the canonical location of metabolic enzymes is the cytosol, discovering their functions in the nucleus will provide advances in the emerging field of studies on the network between metabolism and gene expression. Moreover, it will provide us insights in the impact of metabolic disturbances on chromatin function.


Oliveira SCP, Miyaguti NADS, Russell ST, Tobar N, Geraldo MV, Gomes-Marcondes MCC. Fish Oil Diet during Pre-mating, Gestation, and Lactation in Adult Offspring Rats on Cancer Cachexia Prevention. Mol Nutr Food Res. 2021;65(9):e2000863.


Miyaguti NADS, Stanisic D, Oliveira SCP, et al. Serum and Muscle 1H NMR-Based Metabolomics Profiles Reveal Metabolic Changes Influenced by a Maternal Leucine-Rich Diet in Tumor-Bearing Adult Offspring Rats. Nutrients. 2020;12(7):2106. Published 2020 Jul 16.


Miyaguti NADS, Oliveira SCP, Gomes-Marcondes MCC. Maternal Leucine-Rich Diet Minimises Muscle Mass Loss in Tumour-bearing Adult Rat Offspring by Improving the Balance of Muscle Protein Synthesis and Degradation. Biomolecules. 2019;9(6):229. Published 2019 Jun 13.


Miyaguti NADS, de Oliveira SCP, Gomes-Marcondes MCC. Maternal nutritional supplementation with fish oil and/or leucine improves hepatic function and antioxidant defenses, and minimizes cachexia indexes in Walker-256 tumor-bearing rats offspring. Nutr Res. 2018;51:29-39.