Epigenome rewiring during primate neocortex evolution​

Supervisor: Dr. Boyan Bonev

Enrolled since 2019

I pursued my MSc in Molecular Biology of the Cell at the University of Milan. During my MSc thesis, I was introduced to the fascinating world of non-coding RNAs, studying the role of miRNAs and lncRNAs in the plasticity of the human T lymphocytes. Because of my interest in dissecting the lncRNAs function, I moved to the CRUK in Cambridge where I worked on a project aimed at the characterization of the role of lncRNAs in in vivo hematopoiesis. Due to my passion for gene regulation and non-coding part of the genome, I joined the Bonev Lab in February 2019 as PhD student to work on 3D genome architecture changes during primate evolution focusing on the cerebral cortex. I will investigate this using cerebral organoids derived from macaque, gorilla, orangutan, chimpanzee and human iPSCs.

I like nature, traveling around the world, food in all its aspects and love music and playing the cello.



  • Noack F.*, Vangelisti Silvia*, Ditzer N., Chong F., Albert M. and Bonev B., “Joint epigenome profiling reveals cell-type-specific gene regulatory programmes in human cortical organoids”, Nature Cell Biology, 2023.
  • Florian Noack, Silvia Vangelisti, Madalena Carido, Faye Chong, Boyan Bonev, “Multiomics analysis reveals extensive epigenome remodeling during cortical development”, BioRxiv, 2020.
  • M Joaquina Delás, Benjamin T Jackson*, Tatjana Kovacevic*, Silvia Vangelisti*, Ester Munera Maravilla, Sophia A Wild, Eva Maria Stork, Nicolas Erard, Simon R V Knott, Gregory J Hannon, “lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation”, Cell Reports, 2019.
  • A. Ripamonti, E. Provasi, M. Lorenzo, M. De Simone, V. Ranzani, S. Vangelisti, S. Curti, R. J. P. Bonnal, L. Pignataro, S. Torretta, J. Geginat, G. Rossetti, M. Pagani, and S. Abrignani, “Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells”, PNAS, 2017.