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3D genome architecture changes during primate evolution focusing on the cerebral cortex

I pursued my MSc in Molecular Biology of the Cell at the University of Milan. During my MSc thesis, I was introduced to the fascinating world of non-coding RNAs, studying the role of miRNAs and lncRNAs in the plasticity of the human T lymphocytes. Because of my interest in dissecting the lncRNAs function, I moved to the CRUK in Cambridge where I worked on a project aimed at the characterization of the role of lncRNAs in in vivo hematopoiesis. Due to my passion for gene regulation and non-coding part of the genome, I joined the Bonev Lab in February 2019 as PhD student to work on 3D genome architecture changes during primate evolution focusing on the cerebral cortex. I will investigate this using cerebral organoids derived from macaque, gorilla, orangutan, chimpanzee and human iPSCs.

I like nature, traveling around the world, food in all its aspects and love music and playing the cello.

 

Publications

A. Ripamonti, E. Provasi, M. Lorenzo, M. De Simone, V. Ranzani, S. Vangelisti, S. Curti, R. J. P. Bonnal, L. Pignataro, S. Torretta, J. Geginat, G. Rossetti, M. Pagani, and S. Abrignani, “Repression of miR-31 by BCL6 stabilizes the helper function of human follicular helper T cells”, PNAS, 2017. doi: doi.org/10.1073/pnas.1705364114

M Joaquina DelásBenjamin T Jackson*Tatjana Kovacevic*, Silvia Vangelisti*Ester Munera MaravillaSophia A WildEva Maria StorkNicolas ErardSimon R V KnottGregory J Hannon, “lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation”, Cell Reports, 2019. doi: doi.org/10.1016/j.celrep.2019.03.080

*equal contribution

Florian Noack, Silvia Vangelisti, Madalena Carido, Faye Chong, Boyan Bonev, “Multiomics analysis reveals extensive epigenome remodeling during cortical development”, BioRxiv, 2020. doi: doi.org/10.1101/2020.08.07.241828