Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt

Function of Satellite RNA Transcription for Centromere Assembly and Mitotic Spindle Formation

I accomplished both my bachelor’s and Master’s degree at Chang Gung University, Taiwan. With the background of molecular biology, I am interested in epigenetics which opens a window to explain how fixed DNA sequences interact with changing environments. My previous work was mainly focused on the aberration of epigenetic regulation in cancer cells. By using epigenetic editing technology, I am able to reactivate abnormally silent tumor suppressor genes and even increase the sensitivity to chemotherapy.
Now, I am a PhD student at the Institute of Epigenetics and Stem Cells (IES), Helmholtz center Munich. Under the supervision of Dr. Andreas Ettinger and Dr. Maria-Elena Torres-Padilla, I am eager to unravel the mechanism behind the formation of centromere and aberrant chromosomal segregation during mouse embryonic stem cell division. My project is especially focused on how a non-coding RNA transcribed from centromere involves in spindle formation and the attachment to centromere region. With live-cell imaging techniques in our lab, it enables me to monitor the dynamics of this non-coding RNA within cell cycle and cytokinesis in real-time.