Size-dependent stress signalling in S. Cerevisiae

Supervisor: Dr. Matthew Swaffer

Enrolled since 2025

I earned my Bachelor of Science in Biology and Master of Science in Systems Biology & Quantitative Biology from the University of Zurich in Switzerland. I conducted my master thesis in the lab of Prof. Tuncay Baubec on the DNA methylation dependent binding of zinc finger proteins in mouse embryonic stem cells. I then worked as a Lab Manager and Research Assistant in Prof. Adriano Aguzzi’s group (University Hospital of Zurich) focussing on neurodegenerative diseases, specifically on the effect of prion disease on vacuolisation of neurons. After a brief excurse into the world of industry, I recently joined the Swaffer lab at the University of Edinburgh for my PhD studies and am collaborating with the Schmoller Lab at the Helmholtz Institute as part of the ECB scheme.

My project is focused on understanding how cells respond to the challenges of excessive cell size increases. Specifically, I am investigating the regulation of the stress response in oversized cells. I plan to dissect the signalling pathways involved in the cell’s response to ‘cell size stress’ using yeast genetics, conditional depletion systems, RNA-seq analysis and quantitative live-cell imaging of stress-related transcription factors.